Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory-Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections
Identifieur interne : 002645 ( Main/Exploration ); précédent : 002644; suivant : 002646Household Transmission of the 2009 Pandemic A/H1N1 Influenza Virus: Elevated Laboratory-Confirmed Secondary Attack Rates and Evidence of Asymptomatic Infections
Auteurs : Jesse Papenburg ; Mariana Baz ; Marie-Ève Hamelin ; Chantal Rhéaume ; Julie Carbonneau ; Manale Ouakki ; Isabelle Rouleau ; Isabelle Hardy ; Danuta Skowronski [Canada] ; Michel Roger ; Hugues Charest ; Gaston De Serres ; Guy Boivin [Canada]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2010.
Descripteurs français
- KwdFr :
- ARN viral (génétique), Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Canada, Caractéristiques familiales, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Grippe humaine (transmission), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Infections asymptomatiques (épidémiologie), Jeune adulte, Mâle, Nourrisson, Santé de la famille, Sous-type H1N1 du virus de la grippe A (isolement et purification), Études prospectives.
- MESH :
- génétique : ARN viral.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine, Infections asymptomatiques.
- Adolescent, Adulte, Adulte d'âge moyen, Canada, Caractéristiques familiales, Enfant, Enfant d'âge préscolaire, Facteurs de risque, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Santé de la famille, Études prospectives.
- Pascal (Inist)
- Wicri :
- geographic : Canada.
English descriptors
- KwdEn :
- Adolescent, Adult, Antibodies, Viral (blood), Asymptomatic, Asymptomatic Infections (epidemiology), Canada, Child, Child, Preschool, Family Characteristics, Family Health, Female, H1N1 influenza, Humans, Infant, Infection, Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (epidemiology), Influenza, Human (transmission), Influenza, Human (virology), Laboratory, Male, Middle Aged, Prospective Studies, RNA, Viral (genetics), Risk Factors, Transmission, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- chemical , genetics : RNA, Viral.
- geographic : Canada.
- epidemiology : Asymptomatic Infections, Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- transmission : Influenza, Human.
- virology : Influenza, Human.
- Adolescent, Adult, Child, Child, Preschool, Family Characteristics, Family Health, Female, Humans, Infant, Male, Middle Aged, Prospective Studies, Risk Factors, Young Adult.
Abstract
Background. Characterizing household transmission of the 2009 pandemic A/H1N1 influenza virus (pH1N1) is critical for the design of effective public health measures to mitigate spread. Our objectives were to estimate the secondary attack rates (SARs), the proportion of asymptomatic infections, and risk factors for pH1N1 transmission within households on the basis of active clinical follow-up and laboratory-confirmed outcomes. Methods. We conducted a prospective observational study during the period May-July 2009 (ie, during the first wave of the pH1N1 pandemic) in Quebec City, Canada. We assessed pH1N1 transmission in 42 households (including 43 primary case patients and 119 contacts). Clinical data were prospectively collected during serial household visits. Secondary case patients were identified by clinical criteria and laboratory diagnostic tests, including serological and molecular methods. Results. We identified 53 laboratory-confirmed secondary case patients with pH1N1 virus infection, for an SAR of 45% (95% confidence interval [CI], 35.6%–53.5%). Thirty-four (81%) of the households had ∼1 confirmed secondary case patient. The mean serial interval between onset of primary and confirmed secondary cases was 3.9 days (median interval, 3 days). Influenza-like illness (fever and cough or sore throat) developed in 29% (95% CI, 20.5%–36.7%) of household contacts. Five (9.4%) of secondary case patients were asymptomatic. Young children (<7 years of age) were at highest risk of developing laboratory-confirmed influenza-like illness. Primary case patients with both diarrhea and vomiting were the most likely to transmit pH1N1. Conclusion. Household transmission of pH1N1 may be substantially greater than previously estimated, especially in association with clinical presentations that include gastrointestinal complaints. Approximately 10% of pH1N1 infections acquired in the household may be asymptomatic.
Url:
DOI: 10.1086/656582
Affiliations:
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Le document en format XML
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Hugues" uniqKey="Charest H" first="Hugues" last="Charest">Hugues Charest</name><affiliation><wicri:noCountry code="subField">City</wicri:noCountry></affiliation></author><author><name sortKey="Serres, Gaston De" sort="Serres, Gaston De" uniqKey="Serres G" first="Gaston De" last="Serres">Gaston De Serres</name><affiliation><wicri:noCountry code="subField">City</wicri:noCountry></affiliation></author><author><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Canada</country></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2010</date><biblScope unit="vol">51</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1033">1033</biblScope><biblScope unit="page" to="1041">1041</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Asymptomatic</term><term>Asymptomatic Infections (epidemiology)</term><term>Canada</term><term>Child</term><term>Child, Preschool</term><term>Family Characteristics</term><term>Family Health</term><term>Female</term><term>H1N1 influenza</term><term>Humans</term><term>Infant</term><term>Infection</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (transmission)</term><term>Influenza, Human (virology)</term><term>Laboratory</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>RNA, Viral (genetics)</term><term>Risk Factors</term><term>Transmission</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antiviraux (sang)</term><term>Canada</term><term>Caractéristiques familiales</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Infections asymptomatiques (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Santé de la famille</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Canada</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asymptomatic Infections</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Infections asymptomatiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Family Characteristics</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Canada</term><term>Caractéristiques familiales</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Santé de la famille</term><term>Études prospectives</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Asymptomatique</term><term>Grippe H1N1</term><term>Infection</term><term>Laboratoire</term><term>Transmission</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Canada</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background. Characterizing household transmission of the 2009 pandemic A/H1N1 influenza virus (pH1N1) is critical for the design of effective public health measures to mitigate spread. Our objectives were to estimate the secondary attack rates (SARs), the proportion of asymptomatic infections, and risk factors for pH1N1 transmission within households on the basis of active clinical follow-up and laboratory-confirmed outcomes. Methods. We conducted a prospective observational study during the period May-July 2009 (ie, during the first wave of the pH1N1 pandemic) in Quebec City, Canada. We assessed pH1N1 transmission in 42 households (including 43 primary case patients and 119 contacts). Clinical data were prospectively collected during serial household visits. Secondary case patients were identified by clinical criteria and laboratory diagnostic tests, including serological and molecular methods. Results. We identified 53 laboratory-confirmed secondary case patients with pH1N1 virus infection, for an SAR of 45% (95% confidence interval [CI], 35.6%–53.5%). Thirty-four (81%) of the households had ∼1 confirmed secondary case patient. The mean serial interval between onset of primary and confirmed secondary cases was 3.9 days (median interval, 3 days). Influenza-like illness (fever and cough or sore throat) developed in 29% (95% CI, 20.5%–36.7%) of household contacts. Five (9.4%) of secondary case patients were asymptomatic. Young children (<7 years of age) were at highest risk of developing laboratory-confirmed influenza-like illness. Primary case patients with both diarrhea and vomiting were the most likely to transmit pH1N1. Conclusion. Household transmission of pH1N1 may be substantially greater than previously estimated, especially in association with clinical presentations that include gastrointestinal complaints. Approximately 10% of pH1N1 infections acquired in the household may be asymptomatic.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Baz, Mariana" sort="Baz, Mariana" uniqKey="Baz M" first="Mariana" last="Baz">Mariana Baz</name><name sortKey="Carbonneau, Julie" sort="Carbonneau, Julie" uniqKey="Carbonneau J" first="Julie" last="Carbonneau">Julie Carbonneau</name><name sortKey="Charest, Hugues" sort="Charest, Hugues" uniqKey="Charest H" first="Hugues" last="Charest">Hugues Charest</name><name sortKey="Hamelin, Marie Eve" sort="Hamelin, Marie Eve" uniqKey="Hamelin M" first="Marie-Ève" last="Hamelin">Marie-Ève Hamelin</name><name sortKey="Hardy, Isabelle" sort="Hardy, Isabelle" uniqKey="Hardy I" first="Isabelle" last="Hardy">Isabelle Hardy</name><name sortKey="Ouakki, Manale" sort="Ouakki, Manale" uniqKey="Ouakki M" first="Manale" last="Ouakki">Manale Ouakki</name><name sortKey="Papenburg, Jesse" sort="Papenburg, Jesse" uniqKey="Papenburg J" first="Jesse" last="Papenburg">Jesse Papenburg</name><name sortKey="Rheaume, Chantal" sort="Rheaume, Chantal" uniqKey="Rheaume C" first="Chantal" last="Rhéaume">Chantal Rhéaume</name><name sortKey="Roger, Michel" sort="Roger, Michel" uniqKey="Roger M" first="Michel" last="Roger">Michel Roger</name><name sortKey="Rouleau, Isabelle" sort="Rouleau, Isabelle" uniqKey="Rouleau I" first="Isabelle" last="Rouleau">Isabelle Rouleau</name><name sortKey="Serres, Gaston De" sort="Serres, Gaston De" uniqKey="Serres G" first="Gaston De" last="Serres">Gaston De Serres</name></noCountry><country name="Canada"><noRegion><name sortKey="Skowronski, Danuta" sort="Skowronski, Danuta" uniqKey="Skowronski D" first="Danuta" last="Skowronski">Danuta Skowronski</name></noRegion><name sortKey="Boivin, Guy" sort="Boivin, Guy" uniqKey="Boivin G" first="Guy" last="Boivin">Guy Boivin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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